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Biospex Analyser

The first Raman spectrometer to directly measure cells in liquid samples

Taking Raman
Spectroscopy to a new level

Biospex is the world's first commercial Raman spectrometer that can measure suspended cells directly in liquid samples. Raman-SBT technology is what makes it possible – the simultaneous immobilization and measurement of cells by a laser beam. Biospex has been tested by our customers in areas as wide-ranging as pharmacology, oncology, regenerative medicine and infectious diseases. Biospex can measure the slight differences in chemical cell composition caused by cellular processes such as apoptosis, differentiation and proliferation. It has also proven its effectiveness in identifying cell types and bacterial species.

Automized workflow for easy handling

Biocompatible laser beam

Combinable with other diagnostic methods


Chemical analysis of living cells

The Biospex Analyser is a micro-Raman spectrometer developed to deliver fast and reliable results from biological samples like blood, cell cultures, bacterial cultures and tissues. The laser beam is designed for stress-free examination of living cells, allowing users to monitor changes in the chemical composition of live cells for hours or even days. Since cell physiology is not affected, Raman SBT can also be combined with other analytical methods such as RT-PCR, mass spectrometry, immunofluorescence and FACS.

Raman spectra obtained from a skin cell, displaying the biochemical information

The advantages

Single cells

Cells can be chosen according to morphology and measured separately

Live cells

Cells can be monitored under physiological conditions over a period of hours or days


Non-destructive and label-free technology

Liquid samples

No or minimal pre-analytical workflow increases accuracy and speed


Analysis of a wide variety of cellular macromolecules 

Result classification supported by artificial intelligence

Biospex Raman spectra are interpreted using various optimized machine learning techniques. Classifiers are trained on a Biospex library to recognize spectral signatures. This machine learning aided classification can be used to identify species or cell types and to detect cellular phenomena. The spectral database is constantly growing to expand its accuracy and range of applications.


Application areas


© Siwakorn TH/


Biospex Analyser is ideal for analysing blood. Laser trapping immobilizes the cells, allowing direct analysis of cells in the blood sample and without affecting cell viability.


© H Ko/


The Biospex Raman platform has the capability to display the specific effect of a drug on cells and monitor their response over time. Raman also delivers information on cellular drug uptake into cells or spheroids.


© Alex Traksel/

Food Safety

Identifying food pathogens is a lengthy process, with the risk that contaminated food shipments may reach supermarket shelves before pathogens are detected. Raman-SBT detects foodborne pathogens and pathogenicity factors very rapidly.


© Gorodenkoff/


In many infectious diseases, the gold standard is still laborious cell culture methods that take a lot of time and may delay important treatment decisions. Biospex identifies bacteria and detects changes associated with environmental interactions.


mpx-RamSES: Fast analysis of Raman data

mpx-RamSES (Raman Statistical Evaluation Software) is designed specifically to speed up the analysis of Raman data. Raman spectra are uploaded and automatically processed. The user can choose between various statistical analysis methods such as PCA, LDA, and HCA. One push of a button turns Raman spectra into results. No prior Raman expertise or programming is required.

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