Our unique Raman technology combining micro-Raman spectroscopy and optical trapping supported the researchers in the Transfusion Medicine Department at the Technical University of Dresden, Germany in their endeavours to understand the effect of SARS-CoV-2 virus on blood cells and haemoglobin biosynthesis. The Raman data obtained from patient blood indicated dysregulation of haemoglobin structure and function. This finding sheds more light on the mechanism of SARS-CoV-2, with major implications for diagnostic and therapeutic strategies.